. Author manuscript; available in PMC: 2017 Sep 1.

Published in final edited form as: Genes Immun. 2017 Jan 26;18(2):67–74. doi: 10.1038/gene.2016.51

Table 2.

Association of TLR10, TLR1, and TLR6 Polymorphisms with Organic Dust- Stimulated IL-6 and TNF-α

		Ln IL-6 (pg/mL/lymphocytes)				Ln TNF-α (pg/mL/lymphocytes)
SNP	Gene	¹β_SNP	¹SE_SNP	P-value²	P_adj-value³	¹β_SNP	¹SE_SNP	P-value²	P_adj-value³
rs11466657	TLR10	0.143	0.129	0.27	0.37	0.284	0.159	0.08	0.07
rs11466645		0.127	0.064	0.046	0.008^{^}	0.149	0.078	0.058	0.03
rs11466617		0.132	0.062	0.04	0.006^{^}	0.143	0.076	0.059	0.03
rs7660429		−0.006	0.070	0.93	0.64	0.001	0.085	0.99	0.51
rs11725309		0.156	0.063	0.014^{^}	0.0017^*	0.157	0.078	0.045	0.03
rs3923647	TLR1	0.062	0.141	0.66	0.16	−0.040	0.176	0.82	0.71
rs4833095		0.105	0.058	0.07	0.026^{^}	0.113	0.073	0.12	0.04
rs5743595		0.204	0.062	0.001^*	0.0005^*	0.177	0.077	0.02	0.02
rs5743594		0.011	0.061	0.85	0.66	−0.053	0.075	0.48	0.20
rs5743582		0.007	0.074	0.93	0.78	−0.077	0.090	0.39	0.56
rs5743580		0.202	0.062	0.0012^*	0.0006^*	0.181	0.077	0.02	0.02
rs5743827	TLR6	0.076	0.057	0.18	0.13	−0.063	0.070	0.37	0.40
rs5743815		−0.660	0.160	<0.0001^*	<0.0001^*	−0.319	0.201	0.11	0.13
rs5743795		0.162	0.061	0.0084^{^}	0.0006^*	0.104	0.076	0.17	0.11
rs5743788		0.134	0.064	0.04	0.019^{^}	0.031	0.081	0.70	0.49

SNP-estimates are based on a dominant model. β estimates represent a natural log increase or decrease in stimulated Ln IL-6 and Ln TNF-α (pg/mL/lymphocytes), with the dominant genotype as the reference

Univariate p-value results are from t-tests

Multivariable results (p_adj) are adjusted for age, body mass index, education, sex, race, COPD/smoke and years worked on a farm

Passed the FDR adjustment at 1% level;

^{^}

passed the FDR adjustment at 5% level