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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Genes Immun. 2017 Jan 26;18(2):67–74. doi: 10.1038/gene.2016.51

Table 3.

Association of TLR10, TLR1, and TLR6 Haplotypes with Organic Dust-Stimulated IL-6 and TNF-α Levels

TLR10-TLR1-TLR6
Haplotypes1 		n2 Ln IL-6
(pg/mL/lymphocytes)
β (SE)3 		P-value4 Padj-value5 n2 Ln TNF-α
(pg/mL/lymphocytes)
β (SE)3 		P-value4 Padj-value5
TCATCCGGTG 232 0 Ref6 Ref6 232 0 Ref6 Ref6
CCACCCAGTC 13 0.209 (0.128) 0.10 0.13 13 0.231 (0.155) 0.14 0.12
TCACCCAGTC 67 0.205 (0.065) 0.002 <0.001 67 0.109 (0.078) 0.16 0.12
TCATTCGATC 84 0.088 (0.058) 0.13 0.20 84 −0.019 (0.071) 0.78 0.61
TGATCTGATC 36 0.034 (0.084) 0.68 0.31 36 −0.053 (0.102) 0.61 0.98
Other 77 −0.029 (0.059) 0.62 0.98 77 −0.116 (0.071) 0.10 0.38
1

Haplotypes defined as rs11466657, rs7660429, rs3923647, rs4833095, rs5743594, rs5743582, rs5743580, rs5743827, rs5743815, and rs5743788.

2

Sample sizes estimated from haplotype frequency

3

β represents the change compared to the reference haplotype

4

Univariate p-value results

5

Multivariable results (padj) are adjusted for age, BMI, education, sex, COPD/smoke status, race and years worked on a farm

6

Pairwise comparison to the reference haplotype