. Author manuscript; available in PMC: 2017 Sep 1.

Published in final edited form as: Genes Immun. 2017 Jan 26;18(2):67–74. doi: 10.1038/gene.2016.51

Table 4.

Association of TLR10, TLR1, and TLR6 Polymorphisms with Pam3CSK4- Stimulated IL-6 and TNF-α

		Ln IL-6 (pg/mL/lymphocytes)				Ln TNF-α (pg/mL/lymphocytes)
SNP	Gene	¹β_SNP	¹SE_SNP	P-value²	P_adj-value³	¹β_SNP	¹SE_SNP	P-value²	P_adj-value³
rs11466657	TLR10	0.537	0.186	0.0039^*	0.0077^{^}	0.803	0.224	0.0004^*	0.0008^*
rs11466645		0.610	0.089	<0.0001^*	<0.0001^*	0.822	0.104	<0.0001^*	<0.0001^*
rs11466617		0.614	0.086	<0.0001^*	<0.0001^*	0.823	0.103	<0.0001^*	<0.0001^*
rs7660429		0.150	0.100	0.14	0.14	−0.066	0.121	0.58	0.46
rs11725309		0.614	0.088	<0.0001^*	<0.0001^*	0.848	0.103	<0.0001^*	<0.0001^*
rs3923647	TLR1	0.412	0.208	0.049	0.022^{^}	0.467	0.250	0.063	0.034^{^}
rs4833095		0.666	0.081	<0.0001^*	<0.0001^*	0.880	0.096	<0.0001^*	<0.0001^*
rs5743595		0.658	0.087	<0.0001^*	<0.0001^*	0.912	0.103	<0.0001^*	<0.0001^*
rs5743594		−0.174	0.087	0.047	0.037^{^}	−0.260	0.106	0.015^{^}	0.016^{^}
rs5743582		0.023	0.107	0.83	0.96	−0.302	0.138	0.018^{^}	0.0094^{^}
rs5743580		0.657	0.088	<0.0001^*	<0.0001^*	0.912	0.103	<0.0001^*	<0.0001^*
rs5743827	TLR6	−0.027	0.083	0.74	0.83	−0.265	0.099	0.0076^{^}	0.0078^{^}
rs5743815		−0.728	0.234	0.0019^*	0.0010^*	0.080	0.287	0.78	0.94
rs5743795		0.571	0.086	<0.0001^*	<0.0001^*	0.756	0.103	<0.0001^*	<0.0001^*
rs5743788		0.416	0.094	<0.0001^*	<0.0001^*	0.294	0.114	0.010^{^}	0.012^{^}

SNP-estimates are based on a dominant model. β estimates represent a natural log increase or decrease in stimulated Ln IL-6 and TNF-α (pg/mL/lymphocytes), with the dominant genotype as the reference

Univariate p-value results are from t-tests

Multivariable results (p_adj) are adjusted for age, body mass index, education, sex, race, COPD/smoke and years worked on a farm

Passed the FDR adjustment at 1% level;

^{^}

passed the FDR adjustment at 5% level