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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Genes Immun. 2017 Jan 26;18(2):67–74. doi: 10.1038/gene.2016.51

Table 5.

Association of TLR10, TLR1, and TLR6 Haplotypes with Pam3CSK4-Stimulated IL-6 and TNF-α Levels

TLR10-TLR1-TLR6
Haplotypes1 		n2 Ln IL-6
(pg/mL/lymphocytes)
β (SE)3 		P-value4 Padj-value5 n2 Ln TNF-α
(pg/mL/lymphocytes)
β (SE)3 		P-value4 Padj-value5
TCATCCGGTG 232 0 Ref6 Ref6 232 0 Ref6 Ref6
CCACCCAGTC 13 0.730 (0.175) <0.0001 <0.0001 13 0.764 (0.205) <0.0001 0.001
TCACCCAGTC 67 0.609 (0.087) <0.0001 <0.0001 67 0.669 (0.103) <0.0001 <0.0001
TCATTCGATC 84 0.028 (0.080 0.73 0.74 84 −0.029 (0.089) 0.74 0.78
TGATCTGATC 36 0.158 (0.115) 0.17 0.13 36 −0.128 (0.132) 0.33 0.23
Other 77 0.257 (0.079) 0.001 0.001 77 0.117 (0.093) 0.21 0.23
1

Haplotypes defined as rs11466657, rs7660429, rs3923647, rs4833095, rs5743594, rs5743582, rs5743580, rs5743827, rs5743815, and rs5743788.

2

Sample sizes estimated from haplotype frequency

3

β represents the change compared to the reference haplotype

4

Univariate p-value results

5

Multivariable results (padj) are adjusted for age, BMI, education, sex, COPD/smoke status, race and years worked on a farm

6

Pairwise comparison to the reference haplotype