. Author manuscript; available in PMC: 2017 Sep 1.

Published in final edited form as: Genes Immun. 2017 Jan 26;18(2):67–74. doi: 10.1038/gene.2016.51

Table 6.

Association of TLR10, TLR1, and TLR6 Polymorphisms with Peptidoglycan-Stimulated IL-6 and TNF-α

		Ln IL-6 (pg/mL/lymphocytes)				Ln TNF-α (pg/mL/lymphocytes)
SNP	Gene	¹β_SNP	¹SE_SNP	P-value²	P_adj-value³	¹β_SNP	¹SE_SNP	P-value²	P_adj-value³
rs11466657	TLR10	0.083	0.118	0.48	0.61	0.180	0.158	0.25	0.30
rs11466645		0.059	0.055	0.28	0.24	0.157	0.075	0.037	0.052
rs11466617		0.074	0.055	0.18	0.19	0.168	0.074	0.024	0.037
rs7660429		0.070	0.062	0.25	0.095	0.005	0.083	0.95	0.53
rs11725309		0.084	0.088	0.13	0.093	0.169	0.075	0.026	0.034
rs3923647	TLR1	0.240	0.129	0.064	0.039	0.106	0.176	0.55	0.43
rs4833095		0.088	0.052	0.091	0.041	0.149	0.071	0.036	0.021
rs5743595		0.123	0.055	0.026	0.022	0.215	0.075	0.0042^{^}	0.0058^{^}
rs5743594		0.039	0.054	0.47	0.75	0.042	0.072	0.56	0.86
rs5743582		0.033	0.065	0.61	0.39	−0.041	0.087	0.64	0.97
rs5743580		0.121	0.055	0.029	0.024	0.215	0.075	0.0043^{^}	0.0062^{^}
rs5743827	TLR6	0.094	0.051	0.064	0.054	0.043	0.068	0.53	0.47
rs5743815		−0.472	0.142	0.0009^{^}	0.0006^*	−0.278	0.191	0.15	0.085
rs5743795		0.118	0.055	0.032	0.021	0.129	0.074	0.082	0.11
rs5743788		0.141	0.057	0.014	0.0065^{^}	0.178	0.078	0.023	0.010^{^}

SNP-estimates are based on a dominant model. β estimates represent a natural log increase or decrease in Ln IL-6 or Ln TNF-α, with the dominant genotype as the reference

Univariate p-value results are from t-tests

Multivariable results (p_adj) are adjusted for age, body mass index, education, sex, race, COPD/smoke and years worked on a farm

Passed the FDR adjustment at 1% level;

^{^}

passed the FDR adjustment at 5% level.