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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Genes Immun. 2017 Jan 26;18(2):67–74. doi: 10.1038/gene.2016.51

Table 7.

Association of TLR10, TLR1, and TLR6 Haplotypes with Peptidoglycan-Stimulated IL-6 and TNF-α

TLR10-TLR1-TLR6
Haplotypes1 		n2 Ln IL-6
(pg/mL/lymphocytes)
β (SE)3 		P-value4 Padj-value5 n2 Ln TNF-α
(pg/mL/lymphocytes)
β (SE)3 		P-value4 Padj-value5
TCATCCGGTG 232 0 Ref6 Ref6 232 0 Ref6 Ref6
CCACCCAGTC 13 0.186 (0.116) 0.11 0.18 13 0.245 (0.152) 0.11 0.17
TCACCCAGTC 67 0.152 (0.059) 0.010 0.003 67 0.187 (0.077) 0.015 0.014
TCATTCGATC 84 0.079 (0.053) 0.14 0.18 84 0.069 (0.070) 0.32 0.46
TGATCTGATC 36 0.096 (0.076) 0.21 0.095 36 0.041 (0.100) 0.68 0.48
Other 77 0.042 (0.053) 0.42 0.12 77 −0.035 (0.069) 0.61 0.97
1

Haplotypes defined as rs11466657, rs7660429, rs3923647, rs4833095, rs5743594, rs5743582, rs5743580, rs5743827, rs5743815, and rs5743788.

2

Sample sizes estimated from haplotype frequency

3

β represents the change compared to the reference haplotype

4

Univariate p-value results

5

Multivariable results (padj) are adjusted for age, BMI, education, sex, COPD/smoke status, race and years worked on a farm

6

Pairwise comparison to the reference haplotype