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. 2017 Apr 28;8:505. doi: 10.3389/fimmu.2017.00505

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Copyright © 2017 Adamus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A possible mechanism for the generation of anti-glycolytic proteins antibodies and their role in the induction of the retinal disease process. Antibodies that are generated as a result of tumor, infection, or cell turnover during inflammation may target common antigens (the same specificity antigens) in the retina. Such antibodies can be present in the serum for a long time before clinical presentation of disease occurs. Degenerating tissue can be a source of new antigens that can initiate the further expansion of autoantibodies (AAbs) production and acceleration of disease.