Fig. 3.

Hippocampal seed resting-state functional connectivity differences between LME and HME group. All graphs display values after adjustment for sex, age and education ± SEM. a Erosion of the original AAL hippocampus template (red) resulted in an atrophy-like template (blue) for use as the FC seed. b FC connectivity of right hippocampus, across whole sample (voxel-level p_(FWE-corr) = 0.000005). c LME group showed greater right hippocampal FC with the right middle frontal cortical gyrus (rPFC) than the HME group (k = 237; cluster-level p_(FDR-corr) = 0.022; controlling for sex, age and education years). d The rHIP-rPFC connectivity in the LME group was significantly higher than that in HME group, after controlling for sex, age and education years (F = 26.8, df = 59, p < 0.001). e rHIP-rPFC connectivity was negatively correlated with hippocampal volume, after controlling for age, sex and education year. Unfilled dots indicate HME participants. f Self-rated memory appraisal was positively correlated with rHIP-rPFC connectivity, after controlling for age, sex and education year. Unfilled dots indicate HME participants. NB: Right side of the image indicated the right side of brain