Fig. 2.

ELS has developmental and sex selective effects on NOP performance. T2 fraction for mice during the test phase of the NOP task. T2 fraction was calculated as the ratio (novel object investigation/(novel + familiar object investigation)*100. There was no difference in performance between control male and female mice. (A) For male mice, a significant main effect fo treatment was found, with ELS mice failing to perform above chance at all ages tested. (B) For female mice, ELS led to impaired performance at P21 and P38 but not other developmental time points. *denote significant main effect (ANOVA). ^#denotes significant single sample t-test, comparing T2 fraction to chance (50). ^adenotes an effect approaching but failing to reach significance (p < 0.10). Data represent the group mean (+/-SEM).