Table 7-2.

Validated SNPs for CAD, the Nearest Gene, and the OR From the CARDIoGRAMplusC4D Consortium

SNP	Chromosome	Gene	Effect Size (OR)	Effect Allele Frequency
rs602633	1	SORT1	1.12	0.77
rs17464857	1	MIA3	1.05	0.87
rs17114036	1	PPAP2B	1.11	0.91
rs11206510	1	PCSK9	1.06	0.84
rs4845625	1	IL6R	1.04	0.47
rs6725887	2	WDR12	1.12	0.11
rs515135	2	APOB	1.08	0.82
rs2252641	2	ZEB2-AC074093.1	1.04	0.46
rs1561198	2	VAMP5-VAMP8-GGCX	1.05	0.45
rs6544713	2	ABCG5-ABCG8	1.06	0.30
rs9818870	3	MRAS	1.07	0.14
rs7692387	4	GUCY1A3	1.06	0.81
rs1878406	4	EDNRA	1.06	0.15
rs273909	5	SLC22A4-SLC22A5	1.09	0.14
rs12205331	6	ANKS1A	1.04	0.81
rs9369640	6	PHACTR1	1.09	0.65
rs12190287	6	TCF21	1.07	0.59
rs3798220	6	LPA	1.28	0.01
rs10947789	6	KCNK5	1.06	0.76
rs4252120	6	PLG	1.06	0.73
rs11556924	7	ZC3HC1	1.08	0.65
rs12539895	7	7q22	1.08	0.19
rs2023938	7	HDAC9	1.07	0.10
rs264	8	LPL	1.05	0.86
rs2954029	8	TRIB1	1.04	0.55
rs1333049	9	CDKN2A, CDKN2B	1.23	0.47
rs579459	9	ABO	1.07	0.21
rs2505083	10	KIAA1462	1.06	0.42
rs501120	10	CXCL12	1.07	0.83
rs12413409	10	CYP17A1-CNNM2-NT5C2	1.10	0.89
rs2246833	10	LIPA	1.06	0.38
rs9326246	11	ZNF259-APOA5-A4-C3-A1	1.09	0.10
rs974819	11	PDGFD	1.07	0.29
rs3184504	12	SH2B3	1.07	0.40
rs4773144	13	COL4A1-COL4A2	1.07	0.42
rs9319428	13	FLT1	1.05	0.32
rs2895811	14	HHIPL1	1.06	0.43
rs7173743	15	ADAMTS7	1.07	0.58
rs17514846	15	FURIN-FES	1.05	0.44
rs2281727	17	SMG6-SRR	1.05	0.36
rs12936587	17	RASD1-SMCR3-PEMT	1.06	0.59
rs15563	17	UBE2Z-GIP-ATP5G1-SNF8	1.04	0.52
rs1122608	19	LDLR	1.10	0.76
rs2075650	19	ApoE-ApoC1	1.11	0.14
rs9982601	21	KCNE2	1.13	0.13

CAD indicates coronary artery disease; CARDIoGRAMplusC4D, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIOGRAM) plus the Coronary Artery Disease (C4D) Genetics Consortium; OR, odds ratio; and SNP, single-nucleotide polymorphism.

Data derived from Deloukas et al.¹⁹