Table 1. The 10 novel genome-wide significant loci (p < 5 × 10⁻⁸) associated with eGFRcrea in up to 110,517 subjects from up to 33 studies.

Variant ID	Chr	Position	Index Gene	Effect allele/non-effect allele	Effect allele frequency	Effect (SE)	p-value	I2 (%)	IQ	Number of subjects in analysis
rs10874312	1	82,944,571	LPHN2	A/G	0.67	−0.0057 (0.0011)	2.20 × 10−08	19	1.00	107,335
rs12144044	1	113,248,791	RHOC	A/C	0.28	−0.0061 (0.0011)	2.87 × 10−08	0	0.96	110,517
rs187355703	2	176,993,583	HOXD8	C/G	0.97	0.0182 (0.0030)	5.15 × 10−10	5	0.89	109,257
rs111366116	5	53,295,546	ARL15	T/C	0.11	0.0094 (0.0015)	6.27 × 10−10	22	0.97	110,517
rs113246091	5	67,739,274	PIK3R1	A/G	0.10	−0.0095 (0.0016)	1.98 × 10−09	43	0.98	110,105
rs7764488	6	133,812,872	EYA4	A/G	0.32	0.0061 (0.0011)	4.08 × 10−09	1	0.98	110,516
rs13298297	9	119,264,108	ASTN2	A/G	0.20	−0.0075 (0.0014)	1.53 × 10−08	0	0.81	110,514
rs1111571	16	68,363,181	SLC7A6	A/G	0.71	0.0061 (0.0011)	6.20 × 10−09	0	1.00	109,275
rs9962915	18	5,593,171	EPB41L3	T/C	0.48	−0.0055 (0.0010)	7.19 × 10−09	0	0.98	110,516
rs12458009	18	59,350,507	RNF152	T/G	0.78	−0.0064 (0.0012)	2.90 × 10−08	21	1.00	107,325

Positions are given on GRCh build 37. The gene closest to the variant is listed (index gene). Effect sizes are given on the log scale. IQ = Imputation quality metric computed as median of info score (ImputeV2) or RSQ (minimac) across studies. SE = standard error. I² = between-study heterogeneity statistic.