Table 1. The 10 novel genome-wide significant loci (p < 5 × 10−8) associated with eGFRcrea in up to 110,517 subjects from up to 33 studies.
Variant ID | Chr | Position | Index Gene | Effect allele/non-effect allele | Effect allele frequency | Effect (SE) | p-value | I2 (%) | IQ | Number of subjects in analysis |
---|---|---|---|---|---|---|---|---|---|---|
rs10874312 | 1 | 82,944,571 | LPHN2 | A/G | 0.67 | −0.0057 (0.0011) | 2.20 × 10−08 | 19 | 1.00 | 107,335 |
rs12144044 | 1 | 113,248,791 | RHOC | A/C | 0.28 | −0.0061 (0.0011) | 2.87 × 10−08 | 0 | 0.96 | 110,517 |
rs187355703 | 2 | 176,993,583 | HOXD8 | C/G | 0.97 | 0.0182 (0.0030) | 5.15 × 10−10 | 5 | 0.89 | 109,257 |
rs111366116 | 5 | 53,295,546 | ARL15 | T/C | 0.11 | 0.0094 (0.0015) | 6.27 × 10−10 | 22 | 0.97 | 110,517 |
rs113246091 | 5 | 67,739,274 | PIK3R1 | A/G | 0.10 | −0.0095 (0.0016) | 1.98 × 10−09 | 43 | 0.98 | 110,105 |
rs7764488 | 6 | 133,812,872 | EYA4 | A/G | 0.32 | 0.0061 (0.0011) | 4.08 × 10−09 | 1 | 0.98 | 110,516 |
rs13298297 | 9 | 119,264,108 | ASTN2 | A/G | 0.20 | −0.0075 (0.0014) | 1.53 × 10−08 | 0 | 0.81 | 110,514 |
rs1111571 | 16 | 68,363,181 | SLC7A6 | A/G | 0.71 | 0.0061 (0.0011) | 6.20 × 10−09 | 0 | 1.00 | 109,275 |
rs9962915 | 18 | 5,593,171 | EPB41L3 | T/C | 0.48 | −0.0055 (0.0010) | 7.19 × 10−09 | 0 | 0.98 | 110,516 |
rs12458009 | 18 | 59,350,507 | RNF152 | T/G | 0.78 | −0.0064 (0.0012) | 2.90 × 10−08 | 21 | 1.00 | 107,325 |
Positions are given on GRCh build 37. The gene closest to the variant is listed (index gene). Effect sizes are given on the log scale. IQ = Imputation quality metric computed as median of info score (ImputeV2) or RSQ (minimac) across studies. SE = standard error. I2 = between-study heterogeneity statistic.