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. 2017 Apr 24;5(8):e13204. doi: 10.14814/phy2.13204

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© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of mepyramine on the cage‐exchange stress‐induced changes in T _c (A and B) and L _a (C and D) in light and dark phases. Rats (n = 4–7 per group) were administered with either an IP injection of 30 mg/kg mepyramine (triangles) or physiological saline (circles) at time ‐30 min (arrows), either exposed to cage‐exchange stress (Stress: filled circles) or left undisturbed (Control: empty circles) at time zero for 60 min (black bar), then returned to their home cages in the light (A and C) and dark (B and D) phases. Each point represents mean ± S.E.M. The differences in both T _c and L _a among the groups were compared using two‐way repeated measures ANOVA followed by Bonferroni post hoc test. N in the parentheses = number of animals.