Figure 6.
PLC Inhibition reduces osmotically‐evoked TRPV1 currents. (A) The upper panels show the mean ramp current traces evoked before (black trace) and after (red trace) exposure to hypertonic (345 mosmol kg−1) in the absence (left traces) and presence (right traces) of the PLC inhibitor U73122 (1 μmol/L). The lower traces show the digital subtraction of the black and red traces, which therefore represents the osmotically‐evoked current under the two conditions. (B) The bar graphs show the mean osmotically‐evoked increase in the membrane conductance of MNCs in the two conditions. (C) The bar graphs show the mean peak densities of osmotically‐evoked currents in the two conditions. Data are expressed as mean ± SEM (P < 0.05 is indicated by *).