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. Author manuscript; available in PMC: 2017 Oct 27.
Published in final edited form as: Oncogene. 2016 Oct 31;36(17):2435–2445. doi: 10.1038/onc.2016.399

Figure 1. SALL4 expression is associated with DNA demethylation in a subgroup of HBV-related HCCs.

Figure 1

(a) PCR quantification of SALL4 mRNA in HBV-related HCCs with mild (Left panel) and extreme increase (Right panel) of SALL4 expression. PT, peritumor; T, tumor. (b) Mapping of CpG dinucleotides in human SALL4 gene. The transcriptional start site (TSS), numbered CpG sites, OCT4 and STAT3 binding sites, and the position of bisulfite sequencing primers are indicated. (c–e) Bisulfite sequencing PCR of SALL4 clones, using DNA from patients #24 (c), #72 (d), and #75 (e), as indicated in Fig. 1a. Open and closed circles denote unmethylated and methylated states, respectively.