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Cyclopropanation reactions of natural terpenes and their derivatives. Above: selectivities obtained from Ir(Me)-PIX CYP119 variants identified by directed evolution. Below: The reaction of (−)-carvone with EDA under conditions optimized to produce the product in the highest yield and diastereoselectivity. The yields were determined by GC using dodecane as internal standard. EDA was added slowly using a syringe pump.
