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. 2017 Apr 28;474(10):1579–1590. doi: 10.1042/BCJ20161069

Figure 1. Homology models of Arabidopsis ICS1 and ICS2.

Figure 1.

(A) Primary amino acid sequences for the two Arabidopsis ICS isozymes were submitted to the iTASSER homology modelling server [29] for structural alignment with existing proteins structures. The reference structure, S. marcescens anthranilate synthase (TrpE; PDB accession 1I7Q), is shown alongside the models obtained with this structure for ICS1 and ICS2. α-helices and β-sheets are numbered according to the scheme shown in Supplementary Figure S3; some labels are omitted here for clarity. Amino (N) and carboxy (C) termini are labelled accordingly. ICS1 and ICS2 adopt the same overall structure, with identical arrangement of α-helices and β-sheets, as might be expected for two paralogous proteins. Images obtained using MacPyMOL (http://www.pymol.org). (B) Comparison of ICS1 (pale blue) with E. coli EntC (green), showing very similar active sites.