Table 2. Demographics and clinical characteristics of study participants at enrollment.
| Two feature biomarker | |||||
|---|---|---|---|---|---|
| A-N- (N=93) | A+N- (N=49) | A+N+ (N=21) | A-N+ (N=27) | Total (N=190) | |
| Age | |||||
| Mean (SD) | 74.3 (3.0) | 74.0 (2.6) | 76.4 (3.1) | 75.6 (4.1) | 74.7 (3.2) |
| Median | 73.5 | 73.7 | 76.7 | 74.6 | 73.8 |
| Range | (70.9-84.1) | (70.6-83.2) | (71.2-81.5) | (71.0-83.9) | (70.6-84.1) |
| Over 80 | |||||
| No | 88 (94.6%) | 47 (95.9%) | 17 (81.0%) | 22 (81.5%) | 174 (91.6%) |
| Yes | 5 (5.4%) | 2 (4.1%) | 4 (19.0%) | 5 (18.5%) | 16 (8.4%) |
| Gender | |||||
| Female | 51 (54.8%) | 25 (51.0%) | 8 (38.1%) | 8 (29.6%) | 92 (48.4%) |
| Male | 42 (45.2%) | 24 (49.0%) | 13 (61.9%) | 19 (70.4%) | 98 (51.6%) |
| Education (years) | |||||
| Mean (SD) | 14.3 (2.6) | 14.5 (2.7) | 14.6 (2.3) | 13.8 (2.4) | 14.3 (2.5) |
| Median | 13.0 | 14.0 | 15.0 | 13.0 | 13.0 |
| Range | (12.0-20.0) | (8.0-19.0) | (12.0-19.0) | (11.0-20.0) | (8.0-20.0) |
| Education Category | |||||
| <=12 | 38 (40.9%) | 17 (34.7%) | 7 (33.3%) | 12 (44.4%) | 74 (38.9%) |
| 13-15 | 24 (25.8%) | 12 (24.5%) | 4 (19.0%) | 9 (33.3%) | 49 (25.8%) |
| 16-20 | 31 (33.3%) | 20 (40.8%) | 10 (47.6%) | 6 (22.2%) | 67 (35.3%) |
| Marital Status | |||||
| Single, Never Married | 2 (2.2%) | 3 (6.1%) | 1 (4.8%) | 1 (3.7%) | 7 (3.7%) |
| Married | 72 (77.4%) | 40 (81.6%) | 18 (85.7%) | 18 (66.7%) | 148 (77.9%) |
| Divorced | 7 (7.5%) | 4 (8.2%) | 0 (0.0%) | 3 (11.1%) | 14 (7.4%) |
| Widowed | 12 (12.9%) | 2 (4.1%) | 2 (9.5%) | 5 (18.5%) | 21 (11.1%) |
| Abnormal PiB ratio | |||||
| No | 93 (100.0%) | 0 (0.0%) | 0 (0.0%) | 27 (100.0%) | 120 (63.2%) |
| Yes | 0 (0.0%) | 49 (100.0%) | 21 (100.0%) | 0 (0.0%) | 70 (36.8%) |
| Carrier of APOE e4 allele | |||||
| No | 74 (79.6%) | 27 (55.1%) | 10 (47.6%) | 22 (81.5%) | 133 (70.0%) |
| Yes | 19 (20.4%) | 22 (44.9%) | 11 (52.4%) | 5 (18.5%) | 57 (30.0%) |
| BDI-II Total Score | |||||
| Mean (SD) | 3.3 (3.5) | 4.0 (3.7) | 5.5 (4.6) | 4.1 (5.3) | 3.8 (4.0) |
| Median | 2.0 | 3.0 | 5.0 | 2.0 | 2.0 |
| Range | (0.0-18.0) | (0.0-15.0) | (0.0-20.0) | (0.0-26.0) | (0.0-26.0) |
| BDI depression, Total >=13 | |||||
| Missing | 0 (.%) | 1 (.%) | 0 (.%) | 0 (.%) | 1 |
| 0=No | 91 (97.8%) | 46 (95.8%) | 19 (90.5%) | 26 (96.3%) | 182 (96.3%) |
| 1=Yes | 2 (2.2%) | 2 (4.2%) | 2 (9.5%) | 1 (3.7%) | 7 (3.7%) |
| Any Antidepressant | |||||
| No | 78 (83.9%) | 42 (85.7%) | 18 (85.7%) | 24 (88.9%) | 162 (85.3%) |
| Yes | 15 (16.1%) | 7 (14.3%) | 3 (14.3%) | 3 (11.1%) | 28 (14.7%) |
A-N- = amyloid negative/neurodegeneration negative; A+N- = amyloid positive/neurodegeneration negative; A-N+ = amyloid negative/neurodegeneration positive; A+N+ = amyloid positive/neurodegeneration positive; PiB = Pittsburgh compound B; APOE = apolipoprotein E type; BDI = Beck Depression Inventory