Figure 5.

Specificity of the antibody response elicited to different oligomeric forms of Δ123. (A) Ability of immune sera to bind homologous H77c peptides 408‐428, 430‐451, and 523‐549 and heterologous J6 peptides 408‐428, 430‐451, and 523‐549. P values were determined using the Kruskal‐Wallis test with Dunn's posttest correction for multiple comparison (Prism v 6.0f). (B) Correlation analysis of homologous and heterologous ID₅₀ neutralization titers with homologous and heterologous antibody titers toward peptides 408‐428, 430‐451, and 523‐549 and the ability to inhibit homologous or heterologous E2 binding to CD81. Data were analyzed using Spearman's correlation and the linear regression lines overlaid using Prism (v 7.0a).