Table 2.
Association of clinicopathological characteristics and overall survival
| Primary | Secondary | |||||
|---|---|---|---|---|---|---|
| Parameters | HR | 95% CI | p | HR | 95% CI | p |
| Age (years) | ||||||
| < 60 | 1 | 1 | ||||
| ≥ 60 | 1.54 | 1.04–2.28 | 0.032 | 1.91 | 1.07–3.42 | 0.03 |
| Race | ||||||
| Non-white | 1 | 1 | ||||
| White | 1.47 | 0.85–2.53 | 0.169 | 1.33 | 0.62–2.87 | 0.464 |
| Site | ||||||
| Outer quandrant | 1 | 1 | ||||
| Inner Quandrant | 0.82 | 0.43–1.58 | 0.549 | 1.51 | 0.68–3.34 | 0.307 |
| Central | 0.6 | 0.22–1.61 | 0.311 | 0.97 | 0.38–2.47 | 0.94 |
| Overlapa | 1.45 | 0.83–2.53 | 0.191 | 1.07 | 0.56–2.05 | 0.841 |
| NOSb | 1 | 0.56–1.77 | 0.988 | 0.75 | 0.43–1.32 | 0.315 |
| Nipple | Not calculated | |||||
| Tumor spread | ||||||
| Local | 1 | 1 | ||||
| Regional | 2.66 | 1.69–4.19 | <0.001 | 1.83 | 1.23–2.72 | 0.003 |
| Tumor grade | ||||||
| G1 | 1 | 1 | ||||
| G2 | 1.14 | 0.53–2.44 | 0.746 | 1.79 | 0.65–4.98 | 0.263 |
| G3 | 3.73 | 1.88–7.43 | <0.001 | 2.16 | 0.87–5.34 | 0.097 |
| Gx | 1.6 | 0.79–3.26 | 0.196 | 1.31 | 0.48–3.52 | 0.598 |
| Number of primariesc | ||||||
| 1 (2) | 1 | 1 | ||||
| ≥ 2 (≥ 3) | 1.04 | 0.64–1.70 | 0.866 | 1.3 | 0.88–1.93 | 0.191 |
aMore than one quandrant but less than half breast size
bEntire breast: ¾ or more of breast involved with tumor, or multiple tumors in different subsites
cComparisons were made in 1 versus ≥2 primary tumor groups in primary angiosarcoma and in 2 versus ≥3 primary tumor groups in secondary angiosarcoma