Table 2.
Univariate (log-rank) and multivariate (Cox proportional-harzards) analyses of the association between relapse free survival and clinicopathological factors including EphA3 expression
| Variables | Univariate (log-rank) | Multivariate | |||
|---|---|---|---|---|---|
| 5-years RFS (%) | p | HR | 95% CI | p | |
| Age | |||||
| < 65 | 75.5 | 0.809 | |||
| ≥ 65 | 74.5 | ||||
| Gender | |||||
| Female | 77.1 | 0.655 | |||
| Male | 74.4 | ||||
| Main location | |||||
| Middle or Lower | 80.1 | 0.001 | 1 | ||
| Upper | 55.8 | 1.684 | 0.937–3.029 | 0.082 | |
| WHO pathological type | |||||
| Differentiated | 84 | 0.03 | 1 | ||
| Undifferentiated | 66.3 | 1.616 | 0.841–3.103 | 0.149 | |
| Depth of invasion | |||||
| T1 | 97.7 | <0.001 | 1 | ||
| T2,3,4 | 58.1 | 9.333 | 2.183–39.911 | 0.003 | |
| Lymph node metastasis | |||||
| Negative | 94.7 | <0.001 | 1 | ||
| Positive | 50.5 | 5.734 | 2.349–13.997 | <0.001 | |
| EPHA3 | |||||
| Low | 82.0 | 0.014 | 1 | ||
| High | 67.0 | 1.313 | 0.705–2.447 | 0.391 | |
| HER2 | |||||
| Negative | 75.5 | 0.538 | |||
| Positive | 68.8 | ||||
RFS relapse-free survival, HR harzard ratio, CI confidence interval; P < 0.05, statistically significant