Table 3.
Univariate (log-rank) and multivariate (Cox proportional-harzards) analyses of the association between overalls survival and clinicopathological factors including EphA3 expression
| Variables | Univariate (log-rank) | Multivariate | |||
|---|---|---|---|---|---|
| 5-years OS (%) | p | HR | 95% CI | p | |
| Age | |||||
| < 65 | 76.5 | 0.578 | |||
| ≥ 65 | 74.5 | ||||
| Gender | |||||
| Female | 79.2 | 0.516 | |||
| Male | 74.4 | ||||
| Main location | |||||
| Middle or Lower | 80.1 | 0.001 | 1 | ||
| Upper | 58.1 | 1.654 | 0.907–3.017 | 0.101 | |
| WHO pathological type | |||||
| Differentiated | 83 | 0.01 | 1 | ||
| Undifferentiated | 68.3 | 1.475 | 0.766–2.842 | 0.246 | |
| Depth of invasion | |||||
| T1 | 97.7 | <0.001 | 1 | ||
| T2,3,4 | 59 | 8.785 | 2.038–37.881 | 0.004 | |
| Lymph node metastasis | |||||
| Negative | 94.7 | <0.001 | 1 | ||
| Positive | 51.6 | 5.928 | 2.417–14.537 | <0.001 | |
| EPHA3 | |||||
| Low | 82.0 | 0.026 | 1 | ||
| High | 68.1 | 1.147 | 0.603–2.181 | 0.677 | |
| HER2 | |||||
| Negative | 75.76.15 | 0.431 | |||
| Positive | 68.8 | ||||
OS overall survival, HR harzard ratio, CI confidence interval; P < 0.05; statistically significant