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. 2017 Apr 27;17:294. doi: 10.1186/s12885-017-3279-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Representative photomicrograph of pretreatment biopsy specimens from advanced gastric cancer lesion. a: Immunohistological images of CD42b-positive platelets. Extravasated platelet aggregation (EPA) is mainly seen in the cancer stroma. Cancer-associated fibroblasts (CAFs) with platelet aggregation were observed. b: CAFs in gastric cancer stroma showing D2–40 expression on the membrane, whereas the cancer cells are negative for D2–40 expression. c: SNAIL-positivity expressed in the nuclei of cancer cells. d: Weak expression of forkhead box P3