Table 3.
Characteristics of four biologically and statistically significant DNA methylation sites between Nicoyans and non-Nicoyans
| Probe ID | Pyrosequencing | 450k array | Chr | Distance to closest TSS (bp) | Genomic region: gene | Gene ontology | |||
|---|---|---|---|---|---|---|---|---|---|
| Δβ | p value | Δβ | p value | q value | |||||
| cg02853387 | 0.06 | 7.9E−05 | 0.07 | 1.3E−07 | 0.012 | 11 | 183072 | Intragenic: intron 3 of DSCAML1 | Protein homodimerization activity |
| cg02438481 | 0.08 | 1.9E−05 | 0.08 | 1.6E−07 | 0.012 | 6 | −1861 | Intergenic: C6orf123 | – |
| cg13979274 | 0.06 | 9.1E−07 | 0.06 | 2.0E−07 | 0.012 | 19 | 4347 | Intergenic: ~ 3 kb from 3′ end of OR10H1 | G-protein coupled receptor/olfactory receptor activity |
| cg26107275 | – | – | −0.07 | 2.2E−07 | 0.012 | 12 | −407 | Promoter: BC04264 | – |
Δβ: (Delta beta; absolute mean difference of β values between groups (Nicoyans–non-Nicoyans)
TSS Transcription start site, Chr chromosome