Table 1.
Baseline characteristics of participants by rs12566888 genotypes
| Characteristic | T allele carriers | GG homozygotes | All |
|---|---|---|---|
| N° | 363 | 1575 | 1938 |
| N° with characteristics (%) | |||
| Women | 195 (53.7) | 799 (50.7) | 994 (51.3) |
| Current smoker | 101 (27.8) | 503 (31.9) | 604 (31.2) |
| Drinking alcohol | 112 (30.9) | 448 (28.4) | 560 (28.9) |
| Diabetes mellitus | 3 (0.8) | 29 (1.8) | 32 (1.7) |
| Hypertension | 84 (23.1) | 394 (25.0) | 478 (24.7) |
| Treated hypertension | 39 (10.7) | 169 (10.7) | 208 (10.7) |
| History of CVD | 8 (2.2) | 44 (2.8) | 52 (2.7) |
| Antiplatelet drugs | 70 (19.3) | 305 (19.4) | 375 (19.3) |
| Mean of characteristic (±SD) | |||
| Age, years | 42.8 ± 14.1 | 43.6 ± 14.3 | 43.6 ± 14.3 |
| Body mass index, kg/m2 | 25.6 ± 4.3 | 25.7 ± 4.3 | 25.7 ± 4.3 |
| Waist-to-hip ratio | 0.84 ± 0.09 | 0.85 ± 0.09 | 0.84 ± 0.09 |
| Systolic blood pressure, mm Hg | 124.5 ± 15.2 | 125.3 ± 15.8 | 125.2 ± 15.7 |
| Diastolic blood pressure, mm Hg | 76.0 ± 9.4 | 76.2 ± 9.6 | 76.2 ± 9.5 |
| Mean arterial pressure, mm Hg | 92.2 ± 10.2 | 92.6 ± 10.6 | 92.5 ± 10.5 |
| Heart rate, beats per minute | 69.2 ± 9.5 | 69.4 ± 9.8 | 69.3 ± 9.6 |
| Total cholesterol, mmol/L | 5.47 ± 1.18 | 5.51 ± 1.15 | 5.50 ± 1.15 |
| HDL cholesterol, mmol/L | 1.39 ± 0.41 | 1.39 ± 0.39 | 1.39 ± 0.38 |
| Total-to-HDL cholesterol ratio | 4.31 ± 1.77 | 4.27 ± 1.65 | 4.27 ± 1.67 |
| Serum creatinine, μmol/L | 90.2 ± 16.6 | 91.0 ± 17.3 | 90.9 ± 17.1 |
| Plasma glucose, mmol/L | 5.12 ± 1.55 | 5.03 ± 1.32 | 5.04 ± 1.37 |
Abbreviations: HDL, high-density lipoprotein cholesterol. Mean arterial pressure was diastolic pressure plus one third of the difference of systolic minus diastolic pressure. Diabetes mellitus was a fasting or random plasma glucose level of ≥ 7.0 or ≥11.1 mmol/L (≥126 mg/dL or ≥200 mg/dL), or use of antidiabetic agents. Hypertension was a blood pressure of ≥140 mm Hg systolic or ≥90 mm Hg diastolic or use of antihypertensive drugs. There were no differences between minor allele carriers and major allele homozygotes (0.30 ≤ P ≤ 0.97)