Table 3.
Sensitivity and specificity of echocardiography in determining pulmonary vascular disease during exercise
| n | Cutoff value | Sensitivity | Specificity | AUC (95% CI) | p value | |
|---|---|---|---|---|---|---|
| Quality A TR envelope | 22 | |||||
| MPAP / CO ratio > 3 mmHg/L/min | ||||||
| PASP at peak | ≥ 34 | 82 | 36 | 0.78 (0.57 – 0.98) | 0.03 | |
| MPAP at peak | ≥ 21 | 91 | 55 | 0.84 (0.66 – 1.00) | 0.008 | |
| Δ MPAP | ≥ 10 | 73 | 64 | 0.76 (0.56 – 0.96) | 0.04 | |
| Δ MPAP / 10 Watts | ≥ 1.4 | 91 | 82 | 0.90 (0.77 – 1.00) | 0.001 | |
| Δ PASP / 10 Watts | ≥ 1.9 | 91 | 46 | 0.75 (0.55 – 0.96) | 0.04 | |
| Quality B or C TR envelope | 43 | |||||
| MPAP / CO ratio > 3 mmHg/L/min | ||||||
| PASP at peak | - | - | - | 0.63 (0.46 – 0.81) | 0.19 | |
| MPAP at peak | - | - | - | 0.55 (0.36 – 0.75) | 0.66 | |
| Δ MPAP | - | - | - | 0.40 (0.19 – 0.61) | 0.38 | |
| Δ MPAP / 10 Watts | - | - | - | 0.48 (0.25 – 0.70) | 0.72 | |
| Δ PASP / 10 Watts | - | - | - | 0.54 (0.36 – 0.73) | 0.69 | |
AUC - area under the curve; CI - confidence interval; CO - cardiac output; MPAP - mean pulmonary arterial pressure; PASP - systolic pulmonary arterial pressure; TR - tricuspid regurgitation. AUC is based on receiver-operating characteristic curve analysis. P-values represent results of a test of whether the AUC is significantly different from an AUC of 0.50.