Table 7-2.
Validated SNPs for MI, the Nearest Gene, and the OR From the CARDIoGRAM Consortium
| SNP | Chromosomal Region | Gene | Effect Size (OR) | Minor Allele Frequency |
|---|---|---|---|---|
| rs599839 | 1p13.3 | SORT1 | 1.11 | 0.22 |
| rs17465637 | 1q41 | MIA3 | 1.14 | 0.26 |
| rs17114036 | 1p32.2 | PPAP2B | 1.17 | 0.09 |
| rs11206510 | 1p32.3 | PCSK9 | 1.08 | 0.18 |
| rs6725887 | 2q33 | WDR12 | 1.14 | 0.15 |
| rs2306374 | 3q22.3 | MRAS | 1.12 | 0.18 |
| rs17609940 | 6p21.31 | ANKS1A | 1.07 | 0.25 |
| rs12526453 | 6p24.1 | PHACTR1 | 1.10 | 0.33 |
| rs12190287 | 6q23.2 | TCF21 | 1.08 | 0.38 |
| rs798220 | 6q25 | LPA | 1.51 | 0.02 |
| rs11556924 | 7q32.2 | ZC3HC1 | 1.09 | 0.38 |
| rs4977574 | 9p21.3 | CDKN2A, CDKN2B | 1.29 | 0.46 |
| rs579459 | 9q34.2 | ABO | 1.10 | 0.21 |
| rs1746048 | 10q11 | CXCL12 | 1.09 | 0.13 |
| rs12413409 | 10q24.32 | CYP17A1-CNNM2-NT5C2 | 1.12 | 0.11 |
| rs964184 | 11q23.3 | ZNF259-APOA5-A4-C3-A1 | 1.13 | 0.13 |
| rs3184504 | 12q24 | Sh2b3 | 1.07 | 0.44 |
| rs4773144 | 13q34 | COL4A1-COL4A2 | 1.07 | 0.44 |
| rs2895811 | 14q32.2 | HHIPL1 | 1.08 | 0.43 |
| rs3825807 | 15q25.1 | ADAMTS7 | 1.07 | 0.43 |
| rs216172 | 17p13.3 | SMG6-SRR | 1.07 | 0.37 |
| rs12936587 | 17p11.2 | RASD1-SMCR3-PEMT | 1.07 | 0.44 |
| rs46522 | 17q21.32 | UBE2Z-GIP-ATP5G1-SNF8 | 1.06 | 0.47 |
| rs1122608 | 19q13.2 | LDLR | 1.14 | 0.23 |
| rs9982601 | 21q22.11 | MRPS6 | 1.18 | 0.15 |
SNPs indicates single-nucleotide polymorphisms; MI, myocardial infarction; OR, odds ratio; and CARDIoGRAM, Coronary Artery DIsease Genome-wide Replication And Meta-analysis Consortium.
Data derived from Schunkert et al.9