Table 2. Scope of reaction of P3OT–PFB with nucleophiles.

Nucleophile	Conditions a	Temp.	Time	Conversion b
C12H25–SH	A	70 °C	12 h	Full
	A	RT	24 h	None
	A	70 °C	12 h	Full
C8H17–NH2	A	70 °C	48 h	Full
C8H17–NH2	B	70 °C	12 h	Full
	A	70 °C	48 h	None
	B	70 °C	48 h	None
C5H11–OH	A	70 °C	48 h	None
C5H11–OH	B	70 °C	48 h	None
C5H11–OH	C	70 °C	12 h	Full (disub.)
	A	70 °C	12 h	Full
	A c	70 °C	12 h	Full
	A	RT	48 h	Full

^aReaction conditions: 0.02 μM scale (relative to PFB group), 10 eq. nucleophile, 15 eq. base in a sealed pressure resistant MW vial.

^bConversion as evident from MALDI-TOF and ¹⁹F NMR.

^cAnhydrous conditions.