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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: Curr Mol Med. 2016;16(4):353–393. doi: 10.2174/1566524016666160316152147

Fig. (1).

Fig. (1)

HMGA1a and HMGA1b protein isoforms are depicted with the serine (S) and threonine (T)-rich regions, AT-hook DNA binding domains (AT), and the acidic carboxyl terminal (−) region (top). HMGA1 functions as an architectural transcription factor that bends chromatin to enable binding of transcriptional complexes (bottom).