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Scheme of the synthesis of EETs from unesterified AA catalyzed by CYP450 monooxygenase (Cyp450 MOase). EETs can then be activated by ACSL to produce EET-CoA. Once activated, the EET-CoA can be esterified by a phospholipid acyltransferase such as MBOAT5/LPCAT3, specific to lysophosphatidylcholine and lysophosphatidylethanolamine, or MBOAT7/LPIAT1, specific to lysophosphatidylinositol, to produce oxidized phospholipids.
