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Reduced activation of ABCG1 by LXR in a patient with PAP. A–D: Macrophages isolated from a PAP patient and non-PAP control were plated and treated with a specific LXR agonist (1 μM GW3965) for the indicated time period. ABCG1 (A), ABCA1 (B), IDOL (C), and LPCAT3 (D) activation by LXR. Gene expression was normalized to 36B4 and presented as fold changes. Data are presented as mean ± SEM. Significance was measured by two-way ANOVA followed by Bonferroni correction. *P < 0.001.
