TABLE 2.

Significant associations observed in the trans-ethnic meta-analysis

FA and Gene	SNP	Chr	Position	EA/NEA	EAF, Chinese/Europeans	Chinese		European		MANTRA		METAL
						β (SE)	P	β (SE)	P	BF	Phet	β (SE)	P
Novel associations
18:1n-7
PKD2L1/SCD	rs603424	10	102,065,469	A/G	0.072/0.204	−0.016 (0.009)	0.065	−0.035 (0.004)	5.75 × 10−17	14.8	0.090	−0.032 (0.004)	1.65 × 10−16
FADS1/2	rs174528	11	61,300,075	C/T	0.389/0.368	0.013 (0.005)	3.67 × 10−3	0.021 (0.004)	9.90 × 10−9	8.07	0.023	0.018 (0.003)	7.22 × 10−10
20:1n-9
FADS1/2	rs174601	11	61,379,716	T/C	0.536/0.365	0.008 (0.002)	1.09 × 10−3	0.007 (0.001)	3.99 × 10−38	43.2	0.007	0.007 (0.001)	1.47 × 10−45
GCKR	rs780094	2	27,594,741	T/C	0.490/0.412	−0.002 (0.002)	0.450	−0.002 (0.000)	6.31 × 10−7	6.22	0.007	−0.002 (0.000)	2.95 × 10−8
Previously reported associations
16:1n-7
FADS1/2	rs102275	11	61,314,379	C/T	0.432/0.329	0.021 (0.005)	1.39 × 10−5	0.023 (0.003)a	2.22 × 10−12	14.6	0.006	0.022 (0.003)	2.49 × 10−16
PKD2L1	rs603424	10	102,065,469	A/G	0.073/0.192	−0.023 (0.009)	6.57 × 10−3	−0.032 (0.004)a	5.32 × 10−14	13.0	0.016	−0.030 (0.004)	4.24 × 10−15
GCKR	rs780093	2	27,596,107	T/C	0.524/0.409	0.017 (0.005)	1.36 × 10−4	0.020 (0.003)a	3.42 × 10−9	10.3	0.020	0.019 (0.003)	4.47 × 10−12
HIF1AN	rs10883511	10	102,289,397	G/A	0.143/0.213	0.026 (0.007)	1.90 × 10−4	0.023 (0.004)a	6.44 × 10−8	8.84	0.019	0.024 (0.004)	7.90 × 10−11
18:1n-9
FADS1/2	rs102275	11	61,314,379	C/T	0.419/0.329	0.204 (0.032)	2.92 × 10−10	0.229 (0.020)a	1.10 × 10−31	38.0	0.061	0.222 (0.017)	1.44 × 10−39
LPCAT3	rs12579775	12	6,955,432	A/G	0.032/0.094	−0.539 (0.096)	1.86 × 10−8	0.024 (0.032)a	0.451	6.12	1	−0.034 (0.031)	0.282

Chr, chromosome; EA, effect allele; EAF, effect allele frequency; log₁₀(BF), log₁₀(BF) calculated from MANTRA analyses; NEA, noneffect allele; Phet, Phet between different ethnics.

^aThese results were previously published in European populations from the CHARGE consortium (18).