TABLE 1.
Plasma lipid/lipoprotein levels and HDL subpopulations in carriers of LCAT gene mutations
| Homozygotes | Heterozygotes | Controls | PTrenda | PAnova | |
| n | 15 | 60 | 32 | ||
| Age (years) | 44.1 ± 4.9 | 48.7 ± 2.7 | 46.6 ± 3.6 | 0.86 | 0.73 |
| Gender (male/female) | 14/1 | 39/21 | 11/21 | <0.0001 | 0.0003 |
| Total cholesterol (mg/dl) | 159.6 ± 22.9 | 166.5 ± 5.5 | 193.0 ± 6.5 | 0.015 | 0.03 |
| LDL-C (mg/dl) | 98.5 ± 17.6 | 97.2 ± 5.0 | 111.4 ± 5.5 | 0.21 | 0.30 |
| HDL-C (mg/dl) | 12.1 ± 2.0 | 41.9 ± 2.1 | 59.8 ± 2.3 | <0.0001 | <0.0001 |
| Triglycerides (mg/dl)b | 180 (114–387) | 110.5 (81–154.5) | 77.5 (62–112.5) | 0.0002 | 0.0004 |
| apoA-I (mg/dl) | 50.5 ± 5.7 | 102.1 ± 3.0 | 136.3 ± 4.6 | <0.0001 | <0.0001 |
| apoA-II (mg/dl) | 9.6 ± 1.5 | 29.0 ± 0.8 | 33.9 ± 1.3 | <0.0001 | <0.0001 |
| apoB (mg/dl) | 67.8 ± 13.0 | 92.2 ± 3.5 | 88.6 ± 3.9 | 0.16 | 0.03 |
| LpA-I (mg/dl) | 28.0 ± 4.2 | 46.3 ± 1.7 | 56.4 ± 2.5 | <0.0001 | <0.0001 |
| LpA-I:A-II (mg/dl) | 22.5 ± 4.3 | 55.8 ± 2.4 | 79.8 ± 3.8 | <0.0001 | <0.0001 |
| Preβ HDL (% of apoA-I)b | 40.0 (23.0–49.0) | 16.0 (11.8–22.0) | 12.8 (10.9–14.1) | <0.0001 | <0.0001 |
| HDL2 size (nm) | N.D. | 11.2 ± 0.1 | 11.1 ± 0.1 | 0.15 | 0.35 |
| HDL3 size (nm)b | 7.4 (7.2–7.7) | 9.0 (8.8–9.3) | 9.0 (8.8–9.0) | <0.0001 | <0.0001 |
Data are expressed as mean ± SEM. N.D., not detectable.
a
Adjusted for age, gender, and family, except for age, adjusted for gender and family, and gender, adjusted for age and family.
b
Expressed as median and interquartile range.