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. 2017 Apr 28;58(5):1002–1007. doi: 10.1194/jlr.P075051

Fig. 1.

Fig. 1.

Ratios to enhance selectivity and specificity of the CTX screening assay. A: Rationale of the two selected ratios. Tetrol:t-CDCA ratio: In CTX, tetrol accumulates and CDCA is deficient, yielding a strongly elevated ratio. In Zellweger, tetrol is elevated but CDCA is normal, resulting in a normal or slightly elevated ratio, whereas during cholestasis, CDCA (and CA) is elevated, keeping the ratio low. t-THCA:tetrol ratio: In CTX this ratio is strongly reduced, whereas it is normal or elevated in Zellweger and cholestasis. B: Tetrol:t-CDCA and t-THCA:tetrol ratios in term/preterm controls (triangles), Zellweger (diamonds), newborn CTX, and untreated CTX patients (open/solid circles). The tetrol:t-CDCA ratio is highly discriminative, as it is for Zellweger and CTX. The t-THCA:tetrol ratio also discriminates Zellweger and CTX. C: Table of individual tetrol:t-CDCA and t-THCA:tetrol ratios for CTX patients and ranges for controls (term/preterm) and Zellweger patients.