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. 2017 Apr 28;37(2):BSR20170182. doi: 10.1042/BSR20170182

Figure 1. D. genkwa root extractives change extracellular matrix composition of patients’ granulation tissues.

Figure 1

Expression levels of COL1A1, COL3A1, Timp-1, MMP-3, TGF-β, MEK1/2 and ERK1/2 in granulation tissues. (A) Expression levels of COL1A1, COL3A1, TIMP-1 and MMP-3 in 15 paired granulation tissues by qRT-PCR analysis. The levels of COL1A1, COL3A1, Timp-1 were significantly up-regulated and the level of MMP-3 was statistically reduced after the treatment of root extracts. ***P<0.05 compared with controls, n=10. (B) Western blot analysis of COL1A1, COL3A1, Timp-1, MMP-3, TGF-β, MEK1/2 and ERK1/2 protein expression in representative four paired granulation tissues. The expressions of COL1A1, COL3A1, Timp-1, TGF-β, MEK1/2 and ERK1/2 proteins were obviously elevated while the expression of MMP-3 was remarkably decreased.