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. 2017 Mar 30;9(4):64. doi: 10.3390/v9040064

Figure 2.

Figure 2

The TNF/TNFR pathway is targeted by human immunodeficiency virus 1 (HIV-1) proteins. HIV-1 proteins viral protein R (Vpr), trans-activator of transcription (Tat), negative regulatory factor (Nef), and envelope glycoprotein gp120 interfere with the TNF/TNFR pathway to enhance HIV transcription in infected cells.