Figure 1.

(a) Sequence alignment of dengue virus (DENV) NS5 proteins from the four serotypes. Sequence numbering is according to DENV2 NS5. Secondary structure assignment follows the DENV3 NS5 full-length protein structure (Protein Data Bank (PDB) access code 4V0Q). Specific sequence motifs (A–F) are labeled in red. The linker region is indicated in green. The recently characterized nuclear localization signal is colored in light blue and the priming loop in blue; (b) Superimposition between DENV 3 NS5 (4V0Q, light blue) and Zika virus (ZIKV) NS5 (5TFR, purple) full-length protein structure is represented as α-carbon traces. MTase: methyltransferase; RdRP: RNA-dependent RNA polymerase.