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DENV NS5 interactome. Schematic view of the interactions established by NS5 in the infected cells. In the endoplasmic reticulum (ER) vesicles NS5 interacts with NS3 to replicate and cap the genomic RNA. NS5 brings the STAT2 protein and the URB4 close and triggers the degradation of the formed complex. The C-terminal region is recognized by the Impα2 protein for the import of NS5 protein into the nucleus.
