Treatment Groupa	Mean log10S. pneumoniae (CFU/lung)b ± SD for strain (AMX/CA MIC):
05010S (2 µg/mL)	16001Sc (4 µg/mL)	16001S (4 µg/mL)	30005S (4 µg/mL)	20009S (4 µg/mL)	05003S (8 µg/mL)	404053 (8 µg/mL)	47003S (8 µg/mL)
Control	7.3 ± 0.4	7.0 ± 0.8	5.7 ± 1.2	7.1 ± 0.7	7.1 ± 0.4	6.4 ± 0.6	6.8 ± 0.4	6.0 ± 0.3
AMX/CA
2,000/125 mg b.i.d. (ratio 16:1)	≤ 1.7**	2.8 ± 1.2**	2.2 ± 0.8**	2.3 ± 0.9**	2.5 ± 0.9**	2.0 ± 0.9**	3.8 ± 1.4**	1.8 ± 0.2**
1,000/125 mg t.i.d. (ratio 8:1)	NT	NT	2.8 ± 0.5**	2.7 ± 1.3**	3.3 ± 0.9**	4.9 ± 0.5**	6.6 ± 1.3	4.7 ± 0.7**
875/125 mg t.i.d. (ratio 7:1)	NT	NT	3.0 ± 1.3*	2.1 ± 0.7**	3.2 ± 0.4**	5.2 ± 0.9*	6.4 ± 0.6	4.9 ± 0.4**
875/125 mg b.i.d. (ratio 7:1)	NT	NT	4.5 ± 1.2*	5.6 ± 1.3*	5.2 ± 0.7**	6.3 ± 0.7	6.4 ± 0.7	5.5 ± 0.4
500/125 mg t.i.d. (ratio 4:1)	3.1 ± 1.3**	4.5 ± 0.9**	NT	NT	NT	NT	NT	NT
Azithromycin, 1,000/500 mg o.d.	NT	NT	NT	5.8 ± 2.0	7.1 ± 0.9	3.1 ± 1.0**	6.6 ± 0.4	6.0 ± 0.6
Levofloxacin, 500 mg o.d.	NT	NT	4.2 ± 0.8*	5.7 ± 0.8*	4.9 ± 0.8**	3.0 ± 1.3**	3.5 ± 0.2**	3.9 ± 0.8**
Treatment Groupd	Mean log10H. influenzae (CFU/lung) ± SD for strain:
H128 (β-lactamase positive)	Chesterfield (β-lactamase negative, ampicillin resistant)
Control	6.4 ± 0.6	6.7 ± 0.6
AMX/CA
2,000/125 mg b.i.d. (ratio 16:1)	2.0 ± 0.7**	3.1 ± 0.9**
1,000/125 mg t.i.d. (ratio 8:1)	2.1 ± 1.0**	3.6 ± 1.1**
875/125 mg t.i.d. (ratio 7:1)	2.8 ± 1.3**	3.8 ± 1.3**
875/125 mg b.i.d. (ratio 7:1)	2.0 ± 0.8**	5.1 ± 1.1**
Azithromycin, 1,000/500 mg o.d.	3.2 ± 1.7*	5.8 ± 1.1
Levofloxacin, 500 mg o.d.	≤ 1.7**	≤ 1.7**
a AMX/CA, amoxicillin-clavulanate; b.i.d., twice a day; t.i.d., three times a day; o.d., once a day.
b The limit of detection was <1.7; *, significantly different from the control (P ≤ 0.05); **, significantly different from the control (P ≤ 0.01); NT, not tested.
c Strain 16001S was tested in two separate experiments.
d Amoxicillin-clavulanate 500/125 mg (4:1) three times a day was not tested against the H. influenzae strains.