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. Author manuscript; available in PMC: 2017 Apr 28.
Published in final edited form as: ALTEX. 2016 Feb 11;33(2):95–109. doi: 10.14573/altex.1510052

Tab. 4. Hazard counts for extracted GHS hazards in REACH registrations 2008–2014.

6,186 substances had extractable classification and labeling data in ECHA dossiers.

Description Hazard Labeled substances Conclusive but not sufficient for classification Data lacking Inconclusive Failed extraction
Unstable explosive H200 6 (0.1%) 5507 (89%) 492 (8%) 22 (0.4%) 159 (2.6%)
Explosive; mass explosion hazard H201 14 (0.2%) 5499 (88.9%) 492 (8%) 22 (0.4%) 159 (2.6%)
Fire or projection hazard H204 16 (0.3%) 5497 (88.9%) 492 (8%) 22 (0.4%) 159 (2.6%)
Extremely flammable gas H220 41 (0.7%) 4841 (78.3%) 1122 (18.1%) 23 (0.4%) 159 (2.6%)
Flammable gas H221 2 (0%) 4880 (78.9%) 1122 (18.1%) 23 (0.4%) 159 (2.6%)
Extremely flammable liquid and vapour H224 90 (1.5%) 5047 (81.6%) 877 (14.2%) 13 (0.2%) 159 (2.6%)
Highly flammable liquid and vapour H225 268 (4.3%) 4869 (78.7%) 877 (14.2%) 13 (0.2%) 159 (2.6%)
Flammable liquid and vapour H226 401 (6.5%) 4741 (76.6%) 872 (14.1%) 13 (0.2%) 159 (2.6%)
Combustible liquid H227 2 (0%) 5136 (83%) 876 (14.2%) 13 (0.2%) 159 (2.6%)
Flammable solid H228 68 (1.1%) 5277 (85.3%) 659 (10.7%) 23 (0.4%) 159 (2.6%)
May react explosively even in the absence of air H230 2 (0%) 4880 (78.9%) 1122 (18.1%) 23 (0.4%) 159 (2.6%)
Heating may cause a fire or explosion H241 4 (0.1%) 4879 (78.9%) 1126 (18.2%) 17 (0.3%) 160 (2.6%)
Heating may cause a fire H242 55 (0.9%) 4831 (78.1%) 1123 (18.2%) 17 (0.3%) 160 (2.6%)
Catches fire spontaneously if exposed to air H250 13 (0.2%) 5077 (82.1%) 918 (14.8%) 19 (0.3%) 159 (2.6%)
Self-heating; may catch fire H251 13 (0.2%) 4886 (79%) 1109 (17.9%) 19 (0.3%) 159 (2.6%)
Self-heating in large quantities; may catch fire H252 8 (0.1%) 4892 (79.1%) 1108 (17.9%) 19 (0.3%) 159 (2.6%)
In contact with water releases flammable gases which may ignite spontaneously H260 15 (0.2%) 5076 (82.1%) 914 (14.8%) 22 (0.4%) 159 (2.6%)
In contact with water releases flammable gas H261 8 (0.1%) 5083 (82.2%) 914 (14.8%) 22 (0.4%) 159 (2.6%)
May cause or intensify fire; oxidizer H270 3 (0%) 4862 (78.6%) 1139 (18.4%) 23 (0.4%) 159 (2.6%)
May cause fire or explosion; strong oxidizer H271 15 (0.2%) 5262 (85.1%) 732 (11.8%) 18 (0.3%) 159 (2.6%)
May intensify fire; oxidizer H272 41 (0.7%) 5236 (84.6%) 732 (11.8%) 18 (0.3%) 159 (2.6%)
Contains gas under pressure; may explode if heated H280 60 (1%) 4784 (77.3%) 1161 (18.8%) 22 (0.4%) 159 (2.6%)
Contains refrigerated gas; may cause cryogenic burns or injury H281 1 (0%) 4843 (78.3%) 1161 (18.8%) 22 (0.4%) 159 (2.6%)
May be corrosive to metals H290 125 (2%) 3722 (60.2%) 2155 (34.8%) 25 (0.4%) 159 (2.6%)
Fatal if swallowed H300 33 (0.5%) 5709 (92.3%) 273 (4.4%) 12 (0.2%) 159 (2.6%)
Toxic if swallowed H301 225 (3.6%) 5518 (89.2%) 272 (4.4%) 12 (0.2%) 159 (2.6%)
Harmful if swallowed H302 1072 (17.3%) 4677 (75.6%) 266 (4.3%) 12 (0.2%) 159 (2.6%)
May be harmful if swallowed H303 23 (0.4%) 5720 (92.5%) 272 (4.4%) 12 (0.2%) 159 (2.6%)
May be fatal if swallowed and enters airways H304 453 (7.3%) 2913 (47.1%) 2626 (42.5%) 35 (0.6%) 159 (2.6%)
May be harmful if swallowed and enters airways H305 3 (0%) 3361 (54.3%) 2628 (42.5%) 35 (0.6%) 159 (2.6%)
Fatal in contact with skin H310 30 (0.5%) 4905 (79.3%) 1074 (17.4%) 18 (0.3%) 159 (2.6%)
Toxic in contact with skin H311 164 (2.7%) 4774 (77.2%) 1071 (17.3%) 18 (0.3%) 159 (2.6%)
Harmful in contact with skin H312 209 (3.4%) 4728 (76.4%) 1072 (17.3%) 18 (0.3%) 159 (2.6%)
May be harmful in contact with skin H313 9 (0.1%) 4924 (79.6%) 1076 (17.4%) 18 (0.3%) 159 (2.6%)
Causes severe skin burns and eye damage H314 615 (9.9%) 5105 (82.5%) 290 (4.7%) 16 (0.3%) 160 (2.6%)
Causes skin irritation H315 1010 (16.3%) 4714 (76.2%) 287 (4.6%) 15 (0.2%) 160 (2.6%)
Causes mild skin irritation H316 10 (0.2%) 5706 (92.2%) 294 (4.8%) 16 (0.3%) 160 (2.6%)
May cause an allergic skin reaction H317 1255 (20.3%) 4317 (69.8%) 428 (6.9%) 26 (0.4%) 160 (2.6%)
Causes serious eye damage H318 1087 (17.6%) 4574 (73.9%) 352 (5.7%) 14 (0.2%) 159 (2.6%)
Causes serious eye irritation H319 885 (14.3%) 4762 (77%) 366 (5.9%) 14 (0.2%) 159 (2.6%)
Causes eye irritation H320 44 (0.7%) 5592 (90.4%) 377 (6.1%) 14 (0.2%) 159 (2.6%)
Fatal if inhaled H330 119 (1.9%) 3385 (54.7%) 2480 (40.1%) 43 (0.7%) 159 (2.6%)
Toxic if inhaled H331 188 (3%) 3314 (53.6%) 2482 (40.1%) 43 (0.7%) 159 (2.6%)
Harmful if inhaled H332 446 (7.2%) 3064 (49.5%) 2474 (40%) 43 (0.7%) 159 (2.6%)
May cause allergy or asthma symptoms or breathing difficulties if inhaled H334 127 (2.1%) 2054 (33.2%) 3825 (61.8%) 21 (0.3%) 159 (2.6%)
May cause respiratory irritation H335 377 (6.1%) 4156 (67.2%) 1409 (22.8%) 35 (0.6%) 209 (3.4%)
May cause drowsiness or dizziness H336 207 (3.3%) 4315 (69.8%) 1415 (22.9%) 35 (0.6%) 214 (3.5%)
May cause genetic defects H340 143 (2.3%) 4983 (80.6%) 770 (12.4%) 80 (1.3%) 210 (3.4%)
Suspected of causing genetic defects H341 126 (2%) 5005 (80.9%) 766 (12.4%) 79 (1.3%) 210 (3.4%)
May cause cancer H350 342 (5.5%) 2260 (36.5%) 3373 (54.5%) 24 (0.4%) 187 (3%)
Suspected of causing cancer H351 143 (2.3%) 2460 (39.8%) 3372 (54.5%) 24 (0.4%) 187 (3%)
May damage fertility or the unborn child H360 191 (3.1%) 3854 (62.3%) 1927 (31.2%) 54 (0.9%) 160 (2.6%)
Suspected of damaging fertility or the unborn child H361 370 (6%) 3677 (59.4%) 1925 (31.1%) 54 (0.9%) 160 (2.6%)
May cause harm to breast-fed children H362 9 (0.1%) 2132 (34.5%) 3865 (62.5%) 21 (0.3%) 159 (2.6%)
Causes damage to organs H370 32 (0.5%) 4476 (72.4%) 1414 (22.9%) 35 (0.6%) 229 (3.7%)
May cause damage to organs H371 24 (0.4%) 4485 (72.5%) 1415 (22.9%) 35 (0.6%) 227 (3.7%)
Causes damage to organs through prolonged or repeated exposure H372 258 (4.2%) 4466 (72.2%) 1216 (19.7%) 44 (0.7%) 202 (3.3%)
May cause damage to organs through prolonged or repeated exposure H373 453 (7.3%) 4277 (69.1%) 1212 (19.6%) 44 (0.7%) 200 (3.2%)
Very toxic to aquatic life H400 805 (13%) 4258 (68.8%) 938 (15.2%) 16 (0.3%) 169 (2.7%)
Toxic to aquatic life H401 31 (0.5%) 4893 (79.1%) 1078 (17.4%) 16 (0.3%) 168 (2.7%)
Harmful to aquatic life H402 33 (0.5%) 4888 (79%) 1080 (17.5%) 16 (0.3%) 169 (2.7%)
Very toxic to aquatic life with long-lasting effects H410 715 (11.6%) 4840 (78.2%) 455 (7.4%) 16 (0.3%) 160 (2.6%)
Toxic to aquatic life with long-lasting effects H411 870 (14.1%) 4649 (75.2%) 489 (7.9%) 16 (0.3%) 162 (2.6%)
Harmful to aquatic life with long-lasting effects H412 615 (9.9%) 4904 (79.3%) 489 (7.9%) 16 (0.3%) 162 (2.6%)
May cause long-lasting harmful effects to aquatic life H413 276 (4.5%) 5240 (84.7%) 492 (8%) 16 (0.3%) 162 (2.6%)
Harms public health and the environment by destroying ozone in the upper atmosphere H420 3 (0%) 2706 (43.7%) 3272 (52.9%) 8 (0.1%) 197 (3.2%)