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Biosynthesis of haloduracin β. BH1491 is an uncharacterized protease that has been suggested to remove residues −1 through −6 after cleavage by HalTp at the GS motif.91 Although for clarity the process is drawn as dehydration and then cyclization, the cyclization process commences before dehydration is completed.364,365 See section 4.4.
