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Nonenzymatic and enzymatic cyclization of ProcA substrates containing a single ring installed by ProcM-catalyzed modification of a linear substrate with one Cys protected. In all cases, nonenzymatic cyclization was much slower (A and B). When B ring formation was blocked by Cys protection of ProcA3.3, an incorrect ring topology was favored as characterized for the enzymatic cyclization (B). LP = leader peptide.
