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. 2016 Oct 8;20(3):228–236. doi: 10.1093/ijnp/pyw089

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© The Author 2016. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Effects of MGS0039 and ketamine on alterations in dendritic spine density in the brain regions after social defeat stress. (a) Prelimbic region (PrL) of medial prefrontal cortex (mPFC). (b) Infralimbic region (IL) of mPFC. (c) nucleus Accumbens (NAc) core. (d) NAc shell. (e) Dentate gyrus (DG). (f) CA1. (g) CA3. Scale bar = 10 μm. Values represent the mean ± SEM (n = 6). Representative photomicrographs of Golgi-Cox stained pyramidal neurons in the selected brain regions from animals of each group. ***P < .001 compared with the vehicle + stress group. Ket, ketamine; MGS, MGS0039; Veh, vehicle.