Table 3.
Demographics, Clinical Characteristics,and BDNF Levels of the 41Followed-Up Patients
| Items | Age | Baseline BMI (kg/m 2) | Duration of illness (y) | BDNF protein (ng/mL) at baseline | BDNF protein (ng/mL) at endpoint | Pair t value | P value | 17-Item HDRM at baseline | 17-Item HDRM at endpoint |
|---|---|---|---|---|---|---|---|---|---|
|
Total
(n=41) |
38.1 ± 10.3 | 22.0 ± 3.9 | 1.2 ± 1.9 | 10.7 ± 6.9 | 12.9 ± 11.9 | -1.564 | .126 | 34.5 ± 4.4 | 11.5 ± 11.4 |
| M (n=11) | 42.6 ± 10.6 | 23.1 ± 3.5 | 0.7 ± 1.0 | 9.2 ± 7.2 | 8.5 ± 5.5 | 0.885 | .397 | 35.6 ± 4.0 | 8.2 ± 12.2 |
| F (n=30) | 36.5 ± 9.9 | 21.6 ± 4.0 | 1.4 ± 2.1 | 11.2 ± 6.8 | 14.5 ± 13.2 | -1.751 | .091 | 34.1 ± 4.5 | 12.7 ± 11.1 |
|
Responder
(n=28) |
37.9 ± 10.0 | 22.3 ± 3.6 | 1.2 ± 1.8 | 12.0 ± 7.0 | 15.3 ± 13.3 | -1.640 | .113 | 34.0 ± 4.3 | 4.3 ± 4.0 |
| M (n=9) | 42.9 ± 10.8 | 22.2 ± 3.2 | 0.8 ± 1.1 | 10.4 ± 7.4 | 9.2 ± 5.8 | 1.248 | .247 | 34.4 ± 3.1 | 2.9 ± 3.7 |
| F (n=19) | 35.6 ± 9.0 | 22.3 ± 3.9 | 1.4 ± 2.1 | 12.7 ± 6.8 | 18.1 ± 15.0 | -1.919 | .071 | 33.7 ± 4.8 | 4.9 ± 4.0 |
|
Non-responder
(n=13) |
38.5 ± 11.4 | 21.4 ± 4.4 | 1.3 ± 2.2 | 7.8 ± 6.1 | 7.7 ± 5.4 | 0.288 | .779 | 35.8 ± 4.6 | 27.0 ± 4.1 |
| M (n=2) | 41.5 ± 13.4 | 27.1 ± 0.9 | 0.5 ± 0.4 | 3.6 ± 1.7 | 4.9 ± 2.0 | -5.801 | .109 | 41.0 ± 2.8 | 32.0 ± 0.0 |
| F (n=11) | 38.0 ± 11.7 | 20.4 ± 3.9 | 1.4 ± 2.4 | 8.6 ± 6.3 | 8.2 ± 5.7 | 0.621 | .548 | 34.8 ± 4.2 | 26.2 ± 3.7 |
BMI, body mass index; BDNF, brain-derived neurotrophic factor; 17-item HDRS, 17-item Hamilton Depression Rating Scale.