Table 21.
Comparison of the Presise Algorithm to Previously Developed Guidelines for Acute Bipolar Depression Concerning Monotherapy
| CINP 2016 | WFSBP 2013a | CANMAT and ISBD 2013 | NICE 2014 b | BAP 2016b | |
|---|---|---|---|---|---|
| Lurasidone | 1 | - | 2 | - | 1 |
| Quetiapine | 1 | 1 | 1 | 1 | 1 |
| Escitalopram | 2c | - | - | - | 3 |
| Fluoxetine | 2c | 1 | - | - | 3 |
| Olanzapine | 2 | 1 | 3 | 1 | 1 |
| OFC | 2 | 1 | 1 | 1 | 1 |
| Aripiprazole | 3 | NR | NR | - | - |
| Imipramine | 3 | 4 | |||
| Lamotrigine | 3 | 1 | 1 | 1 | 2 |
| Phenelzin | 3 | - | |||
| Valproate | 3 | 1 | 2 | 1 | - |
| Carbamazepine | 3 | 1 | 3 | - | - |
| Lithium | 4 | 1 | 1 | 1 | 3 |
| Tranylcypromine | 4 | - | - | - | 4 |
| ECT | 5 | - | 3 | - | 5 |
| Gabapentin | NR | - | NR | - | - |
| Leviracetam | - | - | NR | - | - |
| L-thyroxine | - | - | - | - | - |
| Paroxetine | NR | NR | - | - | 3 |
| Risperidone | - | - | NR | - | - |
| rTMS | NR | - | - | - | - |
| Ziprasidone | NR | NR | NR | - | - |
Abbreviations: ECT, electroconvulsive treatment; NR, not recommended;
OFC, olanzapine-fluoxetine combination; rTMS, repetitive Transcranial Magnetic Stimulation.
The grading is not uniform; instead it reflects the grading utilized by individual guidelines and the table aims only to give an image of how different guidelines prioritize treatment options. Numbers correspond to steps not to efficacy ranking.
aWFSBP: Recommendation only reflects monotherapy not considering evidence derived from combination treatment (except OFC).
bNICE and BAP ordering is on the basis of line of treatment.
cAgainst BD-II depression.
NICE ordering is on the basis of line of treatment.