Table 1.
Characteristics of female survivors with at least one recorded delivery episode in Hospital Episode Statistics (HES; n = 1712) and singleton pregnancies of female survivors recorded in HES (n = 2783)
| Characteristic | Individuals (n = 1712) No. (%) | Pregnancies (n = 2783) No. (%) | Excluded pregnancies (n = 120)* No. (%) |
|---|---|---|---|
| Type of childhood cancer | |||
| Leukemia | 546 (31.9) | 915 (32.9) | 32 (26.7) |
| Hodgkin lymphoma | 93 (5.4) | 153 (5.5) | 11 (9.2) |
| Non-Hodgkin lymphoma | 69 (4.0) | 111 (4.0) | 5 (4.2) |
| CNS tumor | 218 (12.7) | 336 (12.1) | 19 (15.8) |
| Neuroblastoma | 85 (5.0) | 135 (4.9) | 5 (4.2) |
| NH-retinoblastoma | 89 (5.2) | 143 (5.1) | 3 (2.5) |
| H-retinoblastoma | 35 (2.0) | 58 (2.1) | 5 (4.2) |
| Wilms tumor | 199 (11.6) | 322 (11.6) | 14 (11.7) |
| Bone tumor | 92 (5.4) | 145 (5.2) | 5 (4.2) |
| Soft-tissue sarcoma | 112 (6.5) | 185 (6.6) | 6 (5.0) |
| Other | 174 (10.2) | 280 (10.1) | 15 (12.5) |
| Type of radiotherapy | |||
| None | 529 (30.9) | 860 (30.9) | 44 (36.7) |
| Brain | 543 (31.7) | 901 (32.4) | 29 (24.2) |
| Other (nonbrain/abdominal) | 146 (8.5) | 231 (8.3) | 12 (10.0) |
| Abdominal | 205 (12.0) | 326 (11.7) | 9 (7.5) |
| Abdominal after: | |||
| Wilms tumor | 127 (7.4) | 207 (7.4) | 3 (2.5) |
| Hodgkin lymphoma | 19 (1.1) | 30 (1.1) | 2 (1.7) |
| Soft-tissue sarcoma | 16 (0.9) | 24 (0.9) | 1 (0.8) |
| Bone tumor | 15 (0.9) | 23 (0.8) | 1 (0.8) |
| Non-Hodgkin lymphoma | 9 (0.5) | 15 (0.5) | 1 (0.8) |
| Neuroblastoma | 7 (0.4) | 10 (0.4) | 0 (0.0) |
| Other | 12 (0.7) | 17 (0.6) | 1 (0.8) |
| Unknown | 289 (16.9) | 465 (16.7) | 26 (21.7) |
| Wilms tumor | |||
| No radiotherapy | 59 (3.4) | 96 (3.4) | 4 (3.3) |
| Abdominal radiotherapy | 127 (7.4) | 207 (7.4) | 3 (2.5) |
| Unknown | 13 (0.8) | 19 (0.7) | 7 (5.8) |
| Age at childhood cancer diagnosis, y | |||
| 0–4 | 802 (46.8) | 1315 (47.3) | 39 (32.5) |
| 5–9 | 481 (28.1) | 781 (28.1) | 49 (40.8) |
| 10–14 | 429 (25.1) | 687 (24.7) | 32 (26.7) |
| Calendar year of childhood cancer | |||
| 1955–1969 | 78 (4.6) | 102 (3.7) | 3 (2.5) |
| 1970–1974 | 175 (10.2) | 246 (8.8) | 13 (10.8) |
| 1975–1979 | 308 (18.0) | 500 (18.0) | 21 (17.5) |
| 1980–1984 | 465 (27.2) | 809 (29.1) | 42 (35.0) |
| 1985–1991 | 686 (40.1) | 1126 (40.5) | 41 (34.2) |
| Maternal age, y | |||
| <18 | 32 (1.9)† | 33 (1.2) | 0 (0.0) |
| 18–24 | 467 (27.3)† | 636 (22.9) | 29 (24.2) |
| 25–29 | 532 (31.1)† | 873 (31.4) | 38 (31.7) |
| 30–34 | 457 (26.7)† | 818 (29.4) | 33 (27.5) |
| ≥35 | 224 (13.1)† | 423 (15.2) | 20 (16.7) |
*
Home deliveries and births in private hospitals (n = 35), as well as pregnancies that resulted in a multiple birth (n = 85), were excluded. CNS = central nervous system; H = heritable; HES = Hospital Episode Statistics; NH = nonheritable.
†
Relates to first recorded delivery episode.