Fig.4.

Representative relationships between changes in MRI volume and cognitive outcomes. For regular insulin-treated participants, improved memory composite Z scores were associated with increased volume for (A) right middle cingulum (r = 0.62, p < 0.05), (B) left cuneus (r = 0.82, p < 0.01), (C) left inferior parietal (r = 0.61, p < 0.04) and (D) right superior frontal (r = 0.67, p < 0.03). For the placebo group, participants who had less volume loss in (C) left inferior parietal or (D) right superior frontal cortex showed less memory decline (rs = 0.65 and 0.64, ps < 0.05). No relationships between ROI volumes and memory were observed for the detemir-treated group.