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. 2017 Apr 4;127(5):1714–1724. doi: 10.1172/JCI84598

Figure 3. A nonneutrophil IL-1–expressing marrow lineage bypasses the requirement for MC in W/Wv mice.

Figure 3

(A) W/Wv mice were injected i.v. with purified B6 bone marrow neutrophils (2 donors/d on days 0–4) or saline control as well as 150 μl i.p. K/BxN serum on days 0 and 2 (n = 5/group; 1 of 2 similar experiments shown). (B) W/Wv mice received whole B6, Wsh, Gfi1–/–, or Il1–/– bone marrow by tail vein (1 donor per 2 recipients), and arthritis was initiated 14 days later as above. Left, clinical scoring (mock engrafted vs. B6 engrafted, P = 0.0001; mock engrafted vs. Wsh engrafted, P = 0.0117; mock engrafted vs. Gfi1–/– engrafted, P = 0.004; mock engrafted vs. Il1–/– engrafted, P = NS). Right, ankle and wrist thickness change (mock engrafted vs. B6 engrafted, P = 0.012; mock engrafted vs. Wsh engrafted, P = 0.03; mock engrafted vs. Gfi1–/– engrafted, P = 0.038; mock engrafted vs. Il1–/– engrafted, P = NS). Mock engrafted, n = 20; B6 engrafted, n = 16; Wsh engrafted, n = 15; Gfi1–/– engrafted, n = 10; Il1–/– engrafted, n = 16; pool of 2–3 experiments.