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. 2017 Apr 4;127(5):1714–1724. doi: 10.1172/JCI84598

Figure 4. The platelet/MK lineage mediates arthritis restoration in W/Wv mice.

Figure 4

(A) W/Wv mice were engrafted with whole Gp1ba–/– bone marrow (1 donor per 2 recipients) and platelet size (forward scatter [FSC]) monitored by flow cytometry at 1 and 2 weeks (n = 3 unengrafted and 5 recipient mice). (B and C) Whole bone marrow was transferred i.v. in W/Wv mice (1 donor per 2 recipients) and arthritis initiated with 150 μl K/BxN serum on days 0 and 2. (B) Clinical score after transfer of NF-E2–/– and control B6 marrow. W/Wv vs. NF-E2–/– engrafted, P = NS; W/Wv vs. B6 engrafted, P = 0.006. n = 8 W/Wv; n = 5 W/Wv + NF-E2–/– (1 fatality); n = 7 W/Wv + B6 (1 failed engraftment); n = 13 WBB6; pooled from 2 experiments. (C) Clinical score after transfer of Gpvi–/–, Gp1ba–/–, and control B6 marrow. W/Wv vs. Gpvi–/– engrafted, P = NS; W/Wv vs. B6, P = 0.026; W/Wv vs. Gp1ba–/– engrafted, P = 0.001. n = 10 W/Wv; n = 10 W/Wv + B6; n = 10 W/Wv + Gpvi–/–; n = 9 W/Wv + Gp1ba–/–; n = 20 WBB6 pooled from 2 experiments.