Figure 1.

Volume loss is accompanied by neuronal loss in 18-month-old CHMP2B^Intron5 mouse brain. (A) High resolution ex vivo MRI results, showing statistically significant FDR-corrected (q = 0.05) t-statistics overlaid on the group-wise registration average image, revealing local structural differences between the brains of the CHMP2B^Intron5 mice (n = 9) relative to non-transgenic controls (n = 10). Regions highlighted in red represent a volume decrease in the CHMP2B^Intron5 brains, and regions highlighted in blue represent a volume increase. Significant volume loss can be readily observed in the thalamus, cortex and brain stem of CHMP2B^Intron5 brains. Sagittal, coronal and horizontal views are shown. (B) Stereological cell counts reveal a significant decrease in neuron number in 18-month-old CHMP2B^Intron5 thalamus (n = 5) when compared with non-transgenic control (n = 5). There is no difference in the total number of cells in the thalamus. *P < 0.05, t-test. Data are shown as mean ± SEM.