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. 2017 Jan 16;26(5):873–887. doi: 10.1093/hmg/ddx003

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Microglial engulfment of dying neurons in aged CHMP2B^Intron5 mouse brain. Confocal analysis of the association of microglia (Iba1⁺, green) with neurons (NeuN⁺, red) in the thalamus of 18-month-old CHMP2B^Intron5 mice. DAPI (blue) stains nuclei and is used to identify apoptotic cells (condensed chromatin). Arrowheads indicate normal neuronal nuclei, stars indicate condensed neuronal nuclei characteristic of apoptosis, which are opposed by microglial processes. Scale bar represents 20 µm.